2h3n: Difference between revisions
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[[Image:2h3n.jpg|left|200px]] | [[Image:2h3n.jpg|left|200px]] | ||
'''Crystal structure of a surrogate light chain (LAMBDA5 and VpreB) homodimer''' | {{Structure | ||
|PDB= 2h3n |SIZE=350|CAPTION= <scene name='initialview01'>2h3n</scene>, resolution 2.3Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= VPREB1, VPREB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), IGLL1, IGL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''Crystal structure of a surrogate light chain (LAMBDA5 and VpreB) homodimer''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2H3N is a [ | 2H3N is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3N OCA]. | ||
==Reference== | ==Reference== | ||
Structural insight into pre-B cell receptor function., Bankovich AJ, Raunser S, Juo ZS, Walz T, Davis MM, Garcia KC, Science. 2007 Apr 13;316(5822):291-4. PMID:[http:// | Structural insight into pre-B cell receptor function., Bankovich AJ, Raunser S, Juo ZS, Walz T, Davis MM, Garcia KC, Science. 2007 Apr 13;316(5822):291-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17431183 17431183] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Bankovich, A J.]] | [[Category: Bankovich, A J.]] | ||
[[Category: Garcia, K C.]] | [[Category: Garcia, K C.]] | ||
[[Category: beta | [[Category: beta sheet]] | ||
[[Category: v- and c-type immunoglobulin fold]] | [[Category: v- and c-type immunoglobulin fold]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:12:12 2008'' | ||
Revision as of 15:12, 20 March 2008
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| 2h3n, resolution 2.3Å | |||||||||||||
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| Gene: | VPREB1, VPREB (Homo sapiens), IGLL1, IGL1 (Homo sapiens) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of a surrogate light chain (LAMBDA5 and VpreB) homodimer
Overview
The pre-B cell receptor (pre-BCR) serves as a checkpoint in B cell development. In the 2.7 angstrom structure of a human pre-BCR Fab-like fragment, consisting of an antibody heavy chain (HC) paired with the surrogate light chain, the "unique regions" of VpreB and lambda5 replace the complementarity-determining region 3 (CDR3) loop of an antibody light chain and appear to "probe" the HC CDR3, potentially influencing the selection of the antibody repertoire. Biochemical analysis indicates that the pre-BCR is impaired in its ability to recognize antigen, which, together with electron microscopic visualization of a pre-BCR dimer, suggests ligand-independent oligomerization as the likely signaling mechanism.
Disease
Known diseases associated with this structure: Agammaglobulinemia, autosomal recessive OMIM:[146770]
About this Structure
2H3N is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural insight into pre-B cell receptor function., Bankovich AJ, Raunser S, Juo ZS, Walz T, Davis MM, Garcia KC, Science. 2007 Apr 13;316(5822):291-4. PMID:17431183
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