4l17: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===GluA2-L483Y-A665C ligand-binding domain in complex with the antagonist DNQX===

The ~~entry 4l17~~ is ~~ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>

~~Authors~~: ~~Lau, A~~.Y.~~, Blachowicz, L~~.~~, Roux, B~~.

==About this Structure==

[[4l17]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L17 OCA].

~~Description~~: ~~GluA2-L483Y-A665C ligand-binding domain in complex with the antagonist DNQX~~

==Reference==

[[Category: Rattus norvegicus]]

[[Category: Blachowicz, L.]]

[[Category: Lau, A Y.]]

[[Category: Roux, B.]]

[[Category: Ion channel]]

[[Category: Membrane]]

[[Category: Neuroreceptor]]

[[Category: Transport protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4l17|  PDB=4l17  |  SCENE=  }}
+===GluA2-L483Y-A665C ligand-binding domain in complex with the antagonist DNQX===
-The entry 4l17 is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
-Authors: Lau, A.Y., Blachowicz, L., Roux, B.
+==About this Structure==
+[[4l17]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L17 OCA].
-Description: GluA2-L483Y-A665C ligand-binding domain in complex with the antagonist DNQX
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Rattus norvegicus]]
+[[Category: Blachowicz, L.]]
+[[Category: Lau, A Y.]]
+[[Category: Roux, B.]]
+[[Category: Ion channel]]
+[[Category: Membrane]]
+[[Category: Neuroreceptor]]
+[[Category: Transport protein]]