2h48: Difference between revisions

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[[Image:2h48.gif|left|200px]]<br /><applet load="2h48" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2h48.gif|left|200px]]
caption="2h48, resolution 2.20&Aring;" />
 
'''Crystal structure of human caspase-1 (Cys362->Ala, Cys364->Ala, Cys397->Ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)'''<br />
{{Structure
|PDB= 2h48 |SIZE=350|CAPTION= <scene name='initialview01'>2h48</scene>, resolution 2.20&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=F3G:3-[2-(2-BENZYLOXYCARBONYLAMINO-3-METHYL-BUTYRYLAMINO)-PROPIONYLAMINO]-4-OXO-PENTANOIC ACID'>F3G</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36]
|GENE= CASP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of human caspase-1 (Cys362->Ala, Cys364->Ala, Cys397->Ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2H48 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=F3G:'>F3G</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H48 OCA].  
2H48 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H48 OCA].  


==Reference==
==Reference==
A common allosteric site and mechanism in caspases., Scheer JM, Romanowski MJ, Wells JA, Proc Natl Acad Sci U S A. 2006 May 16;103(20):7595-600. Epub 2006 May 8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16682620 16682620]
A common allosteric site and mechanism in caspases., Scheer JM, Romanowski MJ, Wells JA, Proc Natl Acad Sci U S A. 2006 May 16;103(20):7595-600. Epub 2006 May 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16682620 16682620]
[[Category: Caspase-1]]
[[Category: Caspase-1]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: z-vad-fmk]]
[[Category: z-vad-fmk]]


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