4l5f: Difference between revisions
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{{STRUCTURE_4l5f| PDB=4l5f | SCENE= }} | |||
===Crystal Structure of DENV1-E106 Fab bound to DENV-1 Envelope protein DIII=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/Q8BE40_9FLAV Q8BE40_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] | |||
==About this Structure== | |||
[[4l5f]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5F OCA]. | |||
[[Category: Mus musculus]] | |||
[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]] | |||
[[Category: Edeling, M A.]] | |||
[[Category: Fremont, D H.]] | |||
[[Category: Nelson, C A.]] | |||
[[Category: Antibody]] | |||
[[Category: Antibody epitope]] | |||
[[Category: Envelope]] | |||
[[Category: Fab]] | |||
[[Category: Immune system]] | |||
[[Category: Infectious disease]] | |||
[[Category: National institute of allergy and infectious disease]] | |||
[[Category: Neutralizing]] | |||
[[Category: Niaid]] | |||
[[Category: Viral protein]] | |||
[[Category: Virus]] | |||
Revision as of 13:49, 11 December 2013
Crystal Structure of DENV1-E106 Fab bound to DENV-1 Envelope protein DIII
Function
[Q8BE40_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
About this Structure
4l5f is a 3 chain structure with sequence from [1] and Mus musculus. Full crystallographic information is available from OCA.
