4l6e: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4l6e|  PDB=4l6e  |  SCENE=  }}
===Crystal Structure of the RanBD1 fourth domain of E3 SUMO-protein ligase RanBP2. Northeast Structural Genomics Consortium (NESG) Target HR9193b===


The entry 4l6e is ON HOLD
==Disease==
[[http://www.uniprot.org/uniprot/RBP2_HUMAN RBP2_HUMAN]] Defects in RANBP2 are the cause of encephalopathy acute infection-induced type 3 (IIAE3) [MIM:[http://omim.org/entry/608033 608033]]. A rapidly progressive encephalopathy manifesting in susceptibile individuals with seizures and coma. It can occur within days in otherwise healthy children after common viral infections such as influenza and parainfluenza, without evidence of viral infection of the brain or inflammatory cell infiltration. Brain T2-weighted magnetic resonance imaging reveals characteristic symmetric lesions present in the thalami, pons and brainstem. Note=Mutations in the RANBP2 gene predispose to IIAE3, but by themselves are insufficient to make the phenotype fully penetrant; additional genetic and environmental factors are required (PubMed:19118815).<ref>PMID:19118815</ref> 


Authors: Vorobiev,S., Su, M., --, --, Seetharaman, J., Mao,L., Xiao,R., Maglaqui,M., Kogan,S., Wang,H., Everett, J.K., Acton, T.B., Montelione, G.T., Hunt,J.F., Tong,L., Northeast Structural Genomics Consortium (NESG)
==Function==
[[http://www.uniprot.org/uniprot/RBP2_HUMAN RBP2_HUMAN]] E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1.<ref>PMID:11792325</ref> <ref>PMID:12032081</ref> <ref>PMID:15378033</ref> <ref>PMID:15931224</ref> 


Description: Crystal Structure of the RanBD1 fourth domain of E3 SUMO-protein ligase RanBP2. Northeast Structural Genomics Consortium (NESG) Target HR9193b.
==About this Structure==
[[4l6e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L6E OCA].
 
==Reference==
<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Acton, T B.]]
[[Category: Everett, J K.]]
[[Category: Hunt, J F.]]
[[Category: Kogan, S.]]
[[Category: Maglaqui, M.]]
[[Category: Mao, L.]]
[[Category: Montelione, G T.]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Seetharaman, J.]]
[[Category: Su, M.]]
[[Category: Tong, L.]]
[[Category: Vorobiev, S.]]
[[Category: Wang, H.]]
[[Category: Xiao, R.]]
[[Category: Isomerase]]
[[Category: Ligase]]
[[Category: Nesg]]
[[Category: Northeast structural genomics consortium]]
[[Category: Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Ranbd1]]
[[Category: Ranbp2]]
[[Category: Structural genomic]]
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