4bl4: Difference between revisions
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==Further structural insights into the binding of complement factor H by complement regulator acquiring surface protein 1, CspA (BbCRASP-1), of Borrelia burgdorferi.== | |||
<StructureSection load='4bl4' size='340' side='right' caption='[[4bl4]], [[Resolution|resolution]] 4.06Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4bl4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi_zs7 Borrelia burgdorferi zs7]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4atr 4atr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BL4 FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bl4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bl4 RCSB], [http://www.ebi.ac.uk/pdbsum/4bl4 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Borrelia burgdorferi has evolved many mechanisms of evading the different immune systems across its range of reservoir hosts, including the capture and presentation of host complement regulators factor H and factor H-like protein-1 (FHL-1). Acquisition is mediated by a family of complement regulator-acquiring surface proteins (CRASPs), of which the atomic structure of CspA (BbCRASP-1) is known and shows the formation of a homodimeric species which is required for binding. Mutagenesis studies have mapped a putative factor H binding site to a cleft between the two subunits. Presented here is a new atomic structure of CspA which shows a degree of flexibility between the subunits which may be critical for factor H scavenging by increasing access to the binding interface and allows the possibility that the assembly can clamp around the bound complement regulators. | |||
Further structural insights into the binding of complement factor H by complement regulator-acquiring surface protein 1 (CspA) of Borrelia burgdorferi.,Caesar JJ, Wallich R, Kraiczy P, Zipfel PF, Lea SM Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):629-33. doi: , 10.1107/S1744309113012748. Epub 2013 May 23. PMID:23722839<ref>PMID:23722839</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Borrelia burgdorferi zs7]] | [[Category: Borrelia burgdorferi zs7]] | ||
[[Category: Caesar, J J.E | [[Category: Caesar, J J.E]] | ||
[[Category: Kraiczy, P | [[Category: Kraiczy, P]] | ||
[[Category: Lea, S M | [[Category: Lea, S M]] | ||
[[Category: Wallich, R | [[Category: Wallich, R]] | ||
[[Category: Zipfel, P F | [[Category: Zipfel, P F]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
Revision as of 09:06, 21 December 2014
Further structural insights into the binding of complement factor H by complement regulator acquiring surface protein 1, CspA (BbCRASP-1), of Borrelia burgdorferi.
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