4knz: Difference between revisions
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New page: {{STRUCTURE_4knz| PDB=4knz | SCENE= }} ===Thymidylate synthase ternary complex with dUMP AND CB3717=== {{ABSTRACT_PUBMED_23611499}} ==Function== [[http://www.uniprot.org/uniprot/TYSY... |
m Protected "4knz" [edit=sysop:move=sysop] |
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Revision as of 13:19, 19 June 2013
Thymidylate synthase ternary complex with dUMP AND CB3717
Template:ABSTRACT PUBMED 23611499
Function
[TYSY_ECOLI] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.
About this Structure
4knz is a 2 chain structure with sequence from Escherichia coli k-12. This structure supersedes the now removed PDB entries and 2g8o. Full crystallographic information is available from OCA.
Reference
- Wang Z, Sapienza PJ, Abeysinghe T, Luzum C, Lee AL, Finer-Moore JS, Stroud RM, Kohen A. Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. J Am Chem Soc. 2013 Apr 23. PMID:23611499 doi:10.1021/ja400761x
