4k69: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[4k69]] is a 1 chain structure | [[4k69]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K69 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:023659209</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:023659209</ref><references group="xtra"/><references/> | ||
[[Category: Chymase]] | [[Category: Chymase]] | ||
[[Category: Collins, B K.]] | [[Category: Collins, B K.]] | ||
[[Category: Padyana, A K.]] | [[Category: Padyana, A K.]] | ||
Revision as of 07:15, 3 July 2013
Crystal Structure of Human Chymase in Complex with Fragment Linked Benzimidazolone Inhibitor: (3S)-3-{3-[(6-bromo-2-oxo-2,3-dihydro-1H-indol-4-yl)methyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}hexanoic acid
Template:ABSTRACT PUBMED 23659209
Function
[CMA1_HUMAN] Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
About this Structure
4k69 is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Taylor SJ, Padyana AK, Abeywardane A, Liang S, Hao MH, De Lombaert S, Proudfoot JR, Farmer BS, Li X, Collins B, Albaugh DR, Martin L, Hill-Drzewi M, Pullen SS, Takahashi H. Discovery of Potent, Selective Chymase Inhibitors via Fragment Linking Strategies. J Med Chem. 2013 May 9. PMID:23659209 doi:10.1021/jm400138z
