2ha5: Difference between revisions

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[[Image:2ha5.gif|left|200px]]<br /><applet load="2ha5" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2ha5.gif|left|200px]]
caption="2ha5, resolution 2.15&Aring;" />
 
'''Crystal structure of mutant S203A of acetylcholinesterase complexed with acetylthiocholine'''<br />
{{Structure
|PDB= 2ha5 |SIZE=350|CAPTION= <scene name='initialview01'>2ha5</scene>, resolution 2.15&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AT3:ACETYLTHIOCHOLINE'>AT3</scene>, <scene name='pdbligand=ETM:2-(TRIMETHYLAMMONIUM)ETHYL+THIOL'>ETM</scene> and <scene name='pdbligand=P6G:HEXAETHYLENE GLYCOL'>P6G</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7]
|GENE=
}}
 
'''Crystal structure of mutant S203A of acetylcholinesterase complexed with acetylthiocholine'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2HA5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=ACT:'>ACT</scene>, <scene name='pdbligand=AT3:'>AT3</scene>, <scene name='pdbligand=ETM:'>ETM</scene> and <scene name='pdbligand=P6G:'>P6G</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HA5 OCA].  
2HA5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HA5 OCA].  


==Reference==
==Reference==
Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding., Bourne Y, Radic Z, Sulzenbacher G, Kim E, Taylor P, Marchot P, J Biol Chem. 2006 Sep 29;281(39):29256-67. Epub 2006 Jul 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16837465 16837465]
Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding., Bourne Y, Radic Z, Sulzenbacher G, Kim E, Taylor P, Marchot P, J Biol Chem. 2006 Sep 29;281(39):29256-67. Epub 2006 Jul 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16837465 16837465]
[[Category: Acetylcholinesterase]]
[[Category: Acetylcholinesterase]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: serine esterase]]
[[Category: serine esterase]]


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