2hal: Difference between revisions

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[[Image:2hal.gif|left|200px]]<br /><applet load="2hal" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2hal.gif|left|200px]]
caption="2hal, resolution 1.35&Aring;" />
 
'''An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors'''<br />
{{Structure
|PDB= 2hal |SIZE=350|CAPTION= <scene name='initialview01'>2hal</scene>, resolution 1.35&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=BBL:N-[(BENZYLOXY)CARBONYL]-L-ALANINE'>BBL</scene>, <scene name='pdbligand=MKE:(4S)-4-AMINO-5-OXOHEXANOIC+ACID'>MKE</scene> and <scene name='pdbligand=EKE:(4S,5R)-4-AMINO-5-HYDROXYHEXANOIC ACID'>EKE</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Picornain_3C Picornain 3C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.28 3.4.22.28]
|GENE= 3C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12092 Hepatitis A virus])
}}
 
'''An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2HAL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus] with <scene name='pdbligand=ACE:'>ACE</scene>, <scene name='pdbligand=BBL:'>BBL</scene>, <scene name='pdbligand=MKE:'>MKE</scene> and <scene name='pdbligand=EKE:'>EKE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Picornain_3C Picornain 3C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.28 3.4.22.28] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAL OCA].  
2HAL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAL OCA].  


==Reference==
==Reference==
An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors., Yin J, Cherney MM, Bergmann EM, Zhang J, Huitema C, Pettersson H, Eltis LD, Vederas JC, James MN, J Mol Biol. 2006 Aug 25;361(4):673-86. Epub 2006 Jul 7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16860823 16860823]
An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors., Yin J, Cherney MM, Bergmann EM, Zhang J, Huitema C, Pettersson H, Eltis LD, Vederas JC, James MN, J Mol Biol. 2006 Aug 25;361(4):673-86. Epub 2006 Jul 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16860823 16860823]
[[Category: Hepatitis a virus]]
[[Category: Hepatitis a virus]]
[[Category: Picornain 3C]]
[[Category: Picornain 3C]]
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[[Category: picornain]]
[[Category: picornain]]


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