2hcc: Difference between revisions
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[[Image:2hcc.gif|left|200px]] | [[Image:2hcc.gif|left|200px]] | ||
'''SOLUTION STRUCTURE OF THE HUMAN CHEMOKINE HCC-2, NMR, 30 STRUCTURES''' | {{Structure | ||
|PDB= 2hcc |SIZE=350|CAPTION= <scene name='initialview01'>2hcc</scene> | |||
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'''SOLUTION STRUCTURE OF THE HUMAN CHEMOKINE HCC-2, NMR, 30 STRUCTURES''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2HCC is a [ | 2HCC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HCC OCA]. | ||
==Reference== | ==Reference== | ||
Solution structure of the human CC chemokine 2: A monomeric representative of the CC chemokine subtype., Sticht H, Escher SE, Schweimer K, Forssmann WG, Rosch P, Adermann K, Biochemistry. 1999 May 11;38(19):5995-6002. PMID:[http:// | Solution structure of the human CC chemokine 2: A monomeric representative of the CC chemokine subtype., Sticht H, Escher SE, Schweimer K, Forssmann WG, Rosch P, Adermann K, Biochemistry. 1999 May 11;38(19):5995-6002. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10320325 10320325] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: nmr structure]] | [[Category: nmr structure]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:15:18 2008'' | ||
Revision as of 15:15, 20 March 2008
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SOLUTION STRUCTURE OF THE HUMAN CHEMOKINE HCC-2, NMR, 30 STRUCTURES
Overview
HCC-2, a 66-amino acid residue human CC chemokine, was reported to induce chemotaxis on monocytes, T-lymphocytes, and eosinophils. The three-dimensional structure of HCC-2 has been determined by 1H nuclear magnetic resonance (NMR) spectroscopy and restrained molecular dynamics calculations on the basis of 871 experimental restraints. The structure is well-defined, exhibiting average root-mean-square deviations of 0.58 and 0.96 A for the backbone heavy atoms and all heavy atoms of residues 5-63, respectively. In contrast to most other chemokines, subtle structural differences impede dimer formation of HCC-2 in a concentration range of 0.1 microM to 2 mM. HCC-2, however, exhibits the same structural elements as the other chemokines, i.e., a triple-stranded antiparallel beta-sheet covered by an alpha-helix, showing that the chemokine fold is not influenced by quaternary interactions. Structural investigations with a HCC-2 mutant prove that a third additional disulfide bond present in wild-type HCC-2 is not necessary for maintaining the relative orientation of the helix and the beta-sheet.
About this Structure
2HCC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of the human CC chemokine 2: A monomeric representative of the CC chemokine subtype., Sticht H, Escher SE, Schweimer K, Forssmann WG, Rosch P, Adermann K, Biochemistry. 1999 May 11;38(19):5995-6002. PMID:10320325
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