2he5: Difference between revisions

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[[Image:2he5.gif|left|200px]]~~<br /><applet load~~="2he5~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:2he5.gif|left|200px]]

~~caption="~~2he5, resolution 2.900Å" />

'''Crystal structure of 17alpha-hydroxysteroid dehydrogenase in binary complex with NADP(H) in an open conformation'''~~<br />~~

{{Structure

|PDB= 2he5 |SIZE=350|CAPTION= <scene name='initialview01'>2he5</scene>, resolution 2.900Å

|SITE=

|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene> and <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>

|ACTIVITY=

|GENE= Akr1c21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])

}}

'''Crystal structure of 17alpha-hydroxysteroid dehydrogenase in binary complex with NADP(H) in an open conformation'''

==Overview==

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==About this Structure==

2HE5 is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus~~] with <scene name='pdbligand=ACT:'>ACT</scene>, <scene name='pdbligand=NDP:'>NDP</scene> and <scene name='pdbligand=BME:'>BME</scene> as [http://en.wikipedia.org/wiki/ligands ligands~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HE5 OCA].

2HE5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HE5 OCA].

==Reference==

Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme., Faucher F, Pereira de Jesus-Tran K, Cantin L, Luu-The V, Labrie F, Breton R, J Mol Biol. 2006 Dec 8;364(4):747-63. Epub 2006 Sep 16. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~17034817 17034817]

Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme., Faucher F, Pereira de Jesus-Tran K, Cantin L, Luu-The V, Labrie F, Breton R, J Mol Biol. 2006 Dec 8;364(4):747-63. Epub 2006 Sep 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17034817 17034817]

[[Category: Mus musculus]]

[[Category: Single protein]]

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[[Category: open conformation]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:15:54 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2he5.gif|left|200px]]<br /><applet load="2he5" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2he5.gif|left|200px]]
-caption="2he5, resolution 2.900&Aring;" />
-'''Crystal structure of 17alpha-hydroxysteroid dehydrogenase in binary complex with NADP(H) in an open conformation'''<br />
+ {{Structure
+|PDB= 2he5 |SIZE=350|CAPTION= <scene name='initialview01'>2he5</scene>, resolution 2.900&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene> and <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>
+|ACTIVITY=
+|GENE= Akr1c21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+}}
+'''Crystal structure of 17alpha-hydroxysteroid dehydrogenase in binary complex with NADP(H) in an open conformation'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-HE5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=ACT:'>ACT</scene>, <scene name='pdbligand=NDP:'>NDP</scene> and <scene name='pdbligand=BME:'>BME</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HE5 OCA].
+HE5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HE5 OCA].
 ==Reference==
-Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme., Faucher F, Pereira de Jesus-Tran K, Cantin L, Luu-The V, Labrie F, Breton R, J Mol Biol. 2006 Dec 8;364(4):747-63. Epub 2006 Sep 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17034817 17034817]
+Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme., Faucher F, Pereira de Jesus-Tran K, Cantin L, Luu-The V, Labrie F, Breton R, J Mol Biol. 2006 Dec 8;364(4):747-63. Epub 2006 Sep 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17034817 17034817]
 [[Category: Mus musculus]]
 [[Category: Single protein]]
@@ Line 30: / Line 39: @@
 [[Category: open conformation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:40:53 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:15:54 2008''