2hhh: Difference between revisions

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[[Image:2hhh.gif|left|200px]]<br /><applet load="2hhh" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2hhh.gif|left|200px]]
caption="2hhh, resolution 3.35&Aring;" />
 
'''Crystal structure of kasugamycin bound to the 30S ribosomal subunit'''<br />
{{Structure
|PDB= 2hhh |SIZE=350|CAPTION= <scene name='initialview01'>2hhh</scene>, resolution 3.35&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=KSG:(1S,2R,3S,4R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL 2-AMINO-4-{[CARBOXY(IMINO)METHYL]AMINO}-2,3,4,6-TETRADEOXY-ALPHA-D-ARABINO-HEXOPYRANOSIDE'>KSG</scene>
|ACTIVITY=
|GENE=
}}
 
'''Crystal structure of kasugamycin bound to the 30S ribosomal subunit'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2HHH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with <scene name='pdbligand=KSG:'>KSG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HHH OCA].  
2HHH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HHH OCA].  


==Reference==
==Reference==
The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation., Schluenzen F, Takemoto C, Wilson DN, Kaminishi T, Harms JM, Hanawa-Suetsugu K, Szaflarski W, Kawazoe M, Shirouzu M, Nierhaus KH, Yokoyama S, Fucini P, Nat Struct Mol Biol. 2006 Oct;13(10):871-8. Epub 2006 Sep 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16998488 16998488]
The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation., Schluenzen F, Takemoto C, Wilson DN, Kaminishi T, Harms JM, Hanawa-Suetsugu K, Szaflarski W, Kawazoe M, Shirouzu M, Nierhaus KH, Yokoyama S, Fucini P, Nat Struct Mol Biol. 2006 Oct;13(10):871-8. Epub 2006 Sep 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16998488 16998488]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
[[Category: Schluenzen, F.]]
[[Category: Schluenzen, F.]]
[[Category: KSG]]
[[Category: KSG]]
[[Category: 30s]]
[[Category: 30]]
[[Category: antibiotics]]
[[Category: antibiotic]]
[[Category: initiation]]
[[Category: initiation]]
[[Category: ribosome]]
[[Category: ribosome]]


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