4is8: Difference between revisions
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{{STRUCTURE_4is8| PDB=4is8 | SCENE= }} | {{STRUCTURE_4is8| PDB=4is8 | SCENE= }} | ||
===Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors=== | ===Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors=== | ||
{{ABSTRACT_PUBMED_23737522}} | |||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4is8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IS8 OCA]. | [[4is8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IS8 OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023737522</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Musille, P M.]] | [[Category: Musille, P M.]] | ||
Revision as of 11:31, 3 July 2013
Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors
Template:ABSTRACT PUBMED 23737522
Function
[NR5A2_HUMAN] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
About this Structure
4is8 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Musille PM, Pathak M, Lauer JL, Griffin PR, Ortlund EA. Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors. J Biol Chem. 2013 Jun 4. PMID:23737522 doi:10.1074/jbc.M113.472837
