4k9t: Difference between revisions
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{{STRUCTURE_4k9t| PDB=4k9t | SCENE= }} | {{STRUCTURE_4k9t| PDB=4k9t | SCENE= }} | ||
===Complex of CYP3A4 with a desoxyritonavir analog=== | ===Complex of CYP3A4 with a desoxyritonavir analog=== | ||
{{ABSTRACT_PUBMED_23746300}} | |||
==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
<references group="xtra"/><references/> | <ref group="xtra">PMID:023746300</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Poulos, T L..]] | [[Category: Poulos, T L..]] | ||
Revision as of 07:08, 30 June 2013
Template:ABSTRACT PUBMED 23746300
Function
[CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.[1]
About this Structure
4k9t is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Sevrioukova IF, Poulos TL. Dissecting Cytochrome P450 3A4-Ligand Interactions Using Ritonavir Analogues. Biochemistry. 2013 Jun 20. PMID:23746300 doi:10.1021/bi4005396
