Cutinase

<StructureSection load='1xzl' size='350' side='right' caption='Structure of cutinase complex with inhibitor hexylphosphonate ethyl ester (PDB entry 1xzl)' scene=>

Cutinase (CUT) catalyzes the conversion of cutin to cutin monomers. Cutin is a main component of the plant cuticle. Polymeric cutin which is composed of hydroxyl and hydroxyepoxy fatty acids is found in the outer layer of plants. CUT is found in fungi and bacteria. CUT degrades the cutin enabling pathogens’ penetration into plant cells. Inhibition of CUT can prevent fungal plant infection. CUT is inhibited by organophosphates like E600 (diethyl-p-nitrophenyl phosphate)) and organophosphonates.

3D Structures of cutinase

Updated on 25-June-2013

1cus, 2cut, 1oxm, 1cex, 1agy, 3qpa – NhCUT – Nectria haematococca
1ffa, 1ffb, 1ffc, 1ffd, 1ffe, 1cua, 1cub, 1cuc, 1cud, 1cue, 1cuf, 1cug, 1cuh, 1cui, 1cuj, 1cuu, 1cufv, 1cuw, 1cux, 1cuy, 1cuz, 1xzb, 1xzc, 1xzd, 1xze, 1xzf, 1xzg, 1xzh, 1xzi, 1xzj – NhCUT (mutant)
3dcn – GcCUT – Glomerella cingulata
3gbs – CUT – Aspergillus oryzae

Cutinase complex with inhibitor

1xzl – NhCUT + hexylphosphonate ethyl ester
1xzk – NhCUT + di-isopropyl phosphate
1xzm – NhCUT + undecyl chloro phosphonate ester
3dd5 – GcCUT + E600
3dea – GcCUT + PETFP
3ef3, 3esa, 3esb, 3eac, 3esd – NhCUT + Pt inhibitor
3qpc – NhCUT + paraoxon
3qpd – NhCUT + phosphoserine

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Michal Harel, Alexander Berchansky