4la6: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "4la6" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4la6| PDB=4la6 | SCENE= }} | |||
===Crystal structure of 2-methylisoborneol synthase from Streptomyces coelicolor A3(2) in complex with Mg2+ and 2-fluoroneryl diphosphate=== | |||
{{ABSTRACT_PUBMED_23844678}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MIBS_STRCO MIBS_STRCO]] Catalyzes the cyclization of 2-methylgeranyl diphosphate (2-MeGPP) to 2-methylisoborneol (2-MIB), which likely involves the intermediacy of 2-methyllinalyl diphosphate. Is also able to catalyze the cyclization of geranyl diphosphate (GPP), albeit with much lower efficiency, leading to the formation of a complex mixture of cyclic monoterpenes, consisting of alpha-pinene (6%), beta-pinene (23%), limonene (32%), gamma-terpinene (29%), and delta-terpinene (10%). | |||
==About this Structure== | |||
[[4la6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor_a3(2) Streptomyces coelicolor a3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LA6 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023844678</ref><references group="xtra"/><references/> | |||
[[Category: 2-methylisoborneol synthase]] | |||
[[Category: Christianson, D W.]] | |||
[[Category: Koksal, M.]] | |||
[[Category: Biosynthesis]] | |||
[[Category: Isoprenoid synthase fold]] | |||
[[Category: Lyase]] | |||
[[Category: Terpenoid biosynthesis]] | |||
Revision as of 05:26, 1 August 2013
Crystal structure of 2-methylisoborneol synthase from Streptomyces coelicolor A3(2) in complex with Mg2+ and 2-fluoroneryl diphosphate
Template:ABSTRACT PUBMED 23844678
Function
[MIBS_STRCO] Catalyzes the cyclization of 2-methylgeranyl diphosphate (2-MeGPP) to 2-methylisoborneol (2-MIB), which likely involves the intermediacy of 2-methyllinalyl diphosphate. Is also able to catalyze the cyclization of geranyl diphosphate (GPP), albeit with much lower efficiency, leading to the formation of a complex mixture of cyclic monoterpenes, consisting of alpha-pinene (6%), beta-pinene (23%), limonene (32%), gamma-terpinene (29%), and delta-terpinene (10%).
About this Structure
4la6 is a 1 chain structure with sequence from Streptomyces coelicolor a3(2). Full crystallographic information is available from OCA.
Reference
- Koksal M, Chou WK, Cane DE, Christianson DW. Unexpected Reactivity of 2-Fluorolinalyl Diphosphate in the Active Site of Crystalline 2-Methylisoborneol Synthase. Biochemistry. 2013 Jul 22. PMID:23844678 doi:10.1021/bi400797c
