4k44: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[4k44]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4k44]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K44 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:023777354</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:023777354</ref><references group="xtra"/><references/> | ||
[[Category: Buffalo rat]] | |||
[[Category: Phosphoinositide phospholipase C]] | [[Category: Phosphoinositide phospholipase C]] | ||
[[Category: Hajicek, N.]] | [[Category: Hajicek, N.]] | ||
[[Category: Sondek, J.]] | [[Category: Sondek, J.]] | ||
Revision as of 06:03, 22 January 2014
Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes
Template:ABSTRACT PUBMED 23777354
Function
[PLCG1_RAT] Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity).
About this Structure
4k44 is a 2 chain structure with sequence from Buffalo rat. Full crystallographic information is available from OCA.
Reference
- Hajicek N, Charpentier TH, Rush JR, Harden TK, Sondek JE. Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes. Biochemistry. 2013 Jun 18. PMID:23777354 doi:10.1021/bi400433b
