4jbm: Difference between revisions
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==Structure of murine DNA binding protein bound with ds DNA== | |||
<StructureSection load='4jbm' size='340' side='right' caption='[[4jbm]], [[Resolution|resolution]] 2.22Å' scene=''> | |||
== Structural highlights == | |||
==Function== | <table><tr><td colspan='2'>[[4jbm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JBM FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jbj|4jbj]], [[4jbk|4jbk]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Aim2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jbm RCSB], [http://www.ebi.ac.uk/pdbsum/4jbm PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/AIM2_MOUSE AIM2_MOUSE]] Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8.<ref>PMID:19158676</ref> <ref>PMID:19158675</ref> <ref>PMID:19131592</ref> <ref>PMID:20417169</ref> <ref>PMID:20351693</ref> <ref>PMID:20351692</ref> <ref>PMID:20457908</ref> <ref>PMID:22555457</ref> <ref>PMID:21902795</ref> | [[http://www.uniprot.org/uniprot/AIM2_MOUSE AIM2_MOUSE]] Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8.<ref>PMID:19158676</ref> <ref>PMID:19158675</ref> <ref>PMID:19131592</ref> <ref>PMID:20417169</ref> <ref>PMID:20351693</ref> <ref>PMID:20351692</ref> <ref>PMID:20457908</ref> <ref>PMID:22555457</ref> <ref>PMID:21902795</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Cheng, G | [[Category: Cheng, G]] | ||
[[Category: Crowley, C | [[Category: Crowley, C]] | ||
[[Category: Ding, W | [[Category: Ding, W]] | ||
[[Category: Hung, L W | [[Category: Hung, L W]] | ||
[[Category: Liu, Z J | [[Category: Liu, Z J]] | ||
[[Category: Ni, X | [[Category: Ni, X]] | ||
[[Category: Ru, H | [[Category: Ru, H]] | ||
[[Category: Shaw, N | [[Category: Shaw, N]] | ||
[[Category: Zhao, L | [[Category: Zhao, L]] | ||
[[Category: Dna]] | [[Category: Dna]] | ||
[[Category: Dna binding protein-dna complex]] | [[Category: Dna binding protein-dna complex]] | ||
[[Category: Ob fold]] | [[Category: Ob fold]] | ||
Revision as of 19:34, 24 December 2014
Structure of murine DNA binding protein bound with ds DNA
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