2hzy: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:2hzy.gif|left|200px]]<br /><applet load="2hzy" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2hzy.gif|left|200px]]
caption="2hzy, resolution 1.35&Aring;" />
 
'''Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate'''<br />
{{Structure
|PDB= 2hzy |SIZE=350|CAPTION= <scene name='initialview01'>2hzy</scene>, resolution 1.35&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=DHJ:4-(2-CARBOXYETHYL)(HYDROXY)PHOSPHORYL]-3-OXOBUTANOIC ACID'>DHJ</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Fumarylacetoacetase Fumarylacetoacetase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.7.1.2 3.7.1.2]
|GENE= Fah ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
}}
 
'''Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate'''
 


==Overview==
==Overview==
Line 7: Line 16:


==About this Structure==
==About this Structure==
2HZY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=MN:'>MN</scene>, <scene name='pdbligand=NI:'>NI</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=DHJ:'>DHJ</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Fumarylacetoacetase Fumarylacetoacetase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.7.1.2 3.7.1.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HZY OCA].  
2HZY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HZY OCA].  


==Reference==
==Reference==
Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics., Bateman RL, Ashworth J, Witte JF, Baker LJ, Bhanumoorthy P, Timm DE, Hurley TD, Grompe M, McClard RW, Biochem J. 2007 Mar 1;402(2):251-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17064256 17064256]
Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics., Bateman RL, Ashworth J, Witte JF, Baker LJ, Bhanumoorthy P, Timm DE, Hurley TD, Grompe M, McClard RW, Biochem J. 2007 Mar 1;402(2):251-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17064256 17064256]
[[Category: Fumarylacetoacetase]]
[[Category: Fumarylacetoacetase]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
Line 23: Line 32:
[[Category: transition-state mimicking complex]]
[[Category: transition-state mimicking complex]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:47:35 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:23:43 2008''
Retrieved from "https://proteopedia.org/2hzy"