2i0a: Difference between revisions

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[[Image:2i0a.jpg|left|200px]]<br /><applet load="2i0a" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2i0a.jpg|left|200px]]
caption="2i0a, resolution 1.80&Aring;" />
 
'''Crystal Structure of KB-19 complexed with wild type HIV-1 protease'''<br />
{{Structure
|PDB= 2i0a |SIZE=350|CAPTION= <scene name='initialview01'>2i0a</scene>, resolution 1.80&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=MUI:(5S)-3-(4-ACETYLPHENYL)-N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL]-2-OXO-1,3-OXAZOLIDINE-5-CARBOXAMIDE'>MUI</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY=
|GENE= pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''Crystal Structure of KB-19 complexed with wild type HIV-1 protease'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2I0A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=MUI:'>MUI</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I0A OCA].  
2I0A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I0A OCA].  


==Reference==
==Reference==
Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands., Ali A, Reddy GS, Cao H, Anjum SG, Nalam MN, Schiffer CA, Rana TM, J Med Chem. 2006 Dec 14;49(25):7342-56. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17149864 17149864]
Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands., Ali A, Reddy GS, Cao H, Anjum SG, Nalam MN, Schiffer CA, Rana TM, J Med Chem. 2006 Dec 14;49(25):7342-56. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17149864 17149864]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: drug design]]
[[Category: drug design]]
[[Category: hiv-1 protease]]
[[Category: hiv-1 protease]]
[[Category: protease inhibitors]]
[[Category: protease inhibitor]]


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