2i0y: Difference between revisions

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[[Image:2i0y.gif|left|200px]]<br /><applet load="2i0y" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2i0y.gif|left|200px]]
caption="2i0y, resolution 1.90&Aring;" />
 
'''cFMS tyrosine kinase (FGF KID) in complex with an arylamide inhibitor'''<br />
{{Structure
|PDB= 2i0y |SIZE=350|CAPTION= <scene name='initialview01'>2i0y</scene>, resolution 1.90&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=5CN:5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE'>5CN</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1]
|GENE=
}}
 
'''cFMS tyrosine kinase (FGF KID) in complex with an arylamide inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2I0Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=5CN:'>5CN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I0Y OCA].  
2I0Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I0Y OCA].  


==Reference==
==Reference==
Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors., Schubert C, Schalk-Hihi C, Struble GT, Ma HC, Petrounia IP, Brandt B, Deckman IC, Patch RJ, Player MR, Spurlino JC, Springer BA, J Biol Chem. 2007 Feb 9;282(6):4094-101. Epub 2006 Nov 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17132624 17132624]
Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors., Schubert C, Schalk-Hihi C, Struble GT, Ma HC, Petrounia IP, Brandt B, Deckman IC, Patch RJ, Player MR, Spurlino JC, Springer BA, J Biol Chem. 2007 Feb 9;282(6):4094-101. Epub 2006 Nov 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17132624 17132624]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Receptor protein-tyrosine kinase]]
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[[Category: tyrosine kinase]]
[[Category: tyrosine kinase]]


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