2i1p: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2i1p.jpg|left|200px]] | [[Image:2i1p.jpg|left|200px]] | ||
'''Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin''' | {{Structure | ||
|PDB= 2i1p |SIZE=350|CAPTION= <scene name='initialview01'>2i1p</scene> | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin''' | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
2I1P is a [ | 2I1P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. | ||
==Reference== | ==Reference== | ||
Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin., Wolf CA, Dancea F, Shi M, Bade-Noskova V, Ruterjans H, Kerjaschki D, Lucke C, J Biomol NMR. 2007 Apr;37(4):321-8. Epub 2007 Jan 24. PMID:[http:// | Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin., Wolf CA, Dancea F, Shi M, Bade-Noskova V, Ruterjans H, Kerjaschki D, Lucke C, J Biomol NMR. 2007 Apr;37(4):321-8. Epub 2007 Jan 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17245526 17245526] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 26: | Line 35: | ||
[[Category: low density lipoprotein receptor]] | [[Category: low density lipoprotein receptor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:24:22 2008'' | ||
Revision as of 15:24, 20 March 2008
| |||||||||||||
| 2i1p | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligands: | CA | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin
Overview
Megalin, an approx. 600 kDa transmembrane glycoprotein that acts as multi-ligand transporter, is a member of the low density lipoprotein receptor gene family. Several cysteine-rich repeats, each consisting of about 40 residues, are responsible for the multispecific binding of ligands. The solution structure of the twelfth cysteine-rich ligand-binding repeat with class A motif found in megalin features two short beta-strands and two helical turns, yielding the typical fold with a I-III, II-V and IV-VI disulfide bridge connectivity pattern and a calcium coordination site at the C-terminal end. The resulting differences in electrostatic surface potential compared to other ligand-binding modules of this gene family, however, may be responsible for the functional divergence.
About this Structure
2I1P is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin., Wolf CA, Dancea F, Shi M, Bade-Noskova V, Ruterjans H, Kerjaschki D, Lucke C, J Biomol NMR. 2007 Apr;37(4):321-8. Epub 2007 Jan 24. PMID:17245526
Page seeded by OCA on Thu Mar 20 17:24:22 2008
