3w0p: Difference between revisions
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{{STRUCTURE_3w0p| PDB=3w0p | SCENE= }} | |||
===Crystal structure of a thermostable mutant of aminoglycoside phosphotransferase APH(4)-Ia (D198A), ternary complex with ADP and hygromycin B=== | |||
{{ABSTRACT_PUBMED_23747390}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/KHYB_ECOLX KHYB_ECOLX]] The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation. Only phosphorylates hygromycin and closely related compounds such as demethyl analogs and destomycin. | |||
==About this Structure== | |||
[[3w0p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0P OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023747390</ref><references group="xtra"/><references/> | |||
[[Category: Escherichia coli]] | |||
[[Category: Hygromycin B 4-O-kinase]] | |||
[[Category: Fukano, K.]] | |||
[[Category: Hoshino, T.]] | |||
[[Category: Iino, D.]] | |||
[[Category: Nakamura, A.]] | |||
[[Category: Ohsawa, K.]] | |||
[[Category: Sasaki, Y.]] | |||
[[Category: Takakura, Y.]] | |||
[[Category: Yajima, S.]] | |||
[[Category: Phosphotransferase]] | |||
[[Category: Transferase-antibiotic complex]] | |||
Revision as of 20:56, 7 August 2013
Crystal structure of a thermostable mutant of aminoglycoside phosphotransferase APH(4)-Ia (D198A), ternary complex with ADP and hygromycin B
Template:ABSTRACT PUBMED 23747390
Function
[KHYB_ECOLX] The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation. Only phosphorylates hygromycin and closely related compounds such as demethyl analogs and destomycin.
About this Structure
3w0p is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
- Iino D, Takakura Y, Fukano K, Sasaki Y, Hoshino T, Ohsawa K, Nakamura A, Yajima S. Crystal structures of the ternary complex of APH(4)-Ia/Hph with hygromycin B and an ATP analog using a thermostable mutant. J Struct Biol. 2013 Jul;183(1):76-85. doi: 10.1016/j.jsb.2013.05.023. Epub 2013, Jun 7. PMID:23747390 doi:10.1016/j.jsb.2013.05.023
