4bvf: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THIOALKYLIMIDATE FORMED FROM THIO-ACETYL-LYSINE ACS2-PEPTIDE CRYSTALLIZED IN PRESENCE OF THE INHIBITOR EX-527===

~~The entry 4bvf is ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN]] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref> [[http://www.uniprot.org/uniprot/ACS2L_HUMAN ACS2L_HUMAN]] Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).<ref>PMID:16788062</ref>

~~Authors~~: ~~GERTZ, M~~.~~, WEYAND, M~~.~~, STEEGBORN, C~~.

==About this Structure==

[[4bvf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BVF OCA].

~~Description~~: ~~CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THIOALKYLIMIDATE FORMED FROM THIO~~-~~ACETYL~~-~~LYSINE ACS2~~-~~PEPTIDE CRYSTALLIZED IN PRESENCE OF THE INHIBITOR EX~~-~~527~~

==Reference==

[[Category: Acetate--CoA ligase]]

[[Category: Homo sapiens]]

[[Category: Gertz, M.]]

[[Category: Steegborn, C.]]

[[Category: Weyand, M.]]

[[Category: Hydrolase-hydrolase]]

[[Category: Hydrolase-ligase complex]]

[[Category: Thio-intermediate]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4bvf|  PDB=4bvf  |  SCENE=  }}
+===CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THIOALKYLIMIDATE FORMED FROM THIO-ACETYL-LYSINE ACS2-PEPTIDE CRYSTALLIZED IN PRESENCE OF THE INHIBITOR EX-527===
+{{ABSTRACT_PUBMED_23840057}}
-The entry 4bvf is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN]] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref>  [[http://www.uniprot.org/uniprot/ACS2L_HUMAN ACS2L_HUMAN]] Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).<ref>PMID:16788062</ref>
-Authors: GERTZ, M., WEYAND, M., STEEGBORN, C.
+==About this Structure==
+[[4bvf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BVF OCA].
-Description: CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THIOALKYLIMIDATE FORMED FROM THIO-ACETYL-LYSINE ACS2-PEPTIDE CRYSTALLIZED IN PRESENCE OF THE INHIBITOR EX-527
+==Reference==
+<ref group="xtra">PMID:023840057</ref><references group="xtra"/><references/>
+[[Category: Acetate--CoA ligase]]
+[[Category: Homo sapiens]]
+[[Category: Gertz, M.]]
+[[Category: Steegborn, C.]]
+[[Category: Weyand, M.]]
+[[Category: Hydrolase-hydrolase]]
+[[Category: Hydrolase-ligase complex]]
+[[Category: Thio-intermediate]]