4iop: Difference between revisions
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{{STRUCTURE_4iop| PDB=4iop | SCENE= }} | |||
===Crystal structure of NKp65 bound to its ligand KACL=== | |||
{{ABSTRACT_PUBMED_23803857}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CLC2A_HUMAN CLC2A_HUMAN]] Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.<ref>PMID:18550855</ref> <ref>PMID:20194751</ref> [[http://www.uniprot.org/uniprot/KLRF2_HUMAN KLRF2_HUMAN]] C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A. | |||
==About this Structure== | |||
[[4iop]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOP OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023803857</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Li, Y.]] | |||
[[Category: Immune system]] | |||
[[Category: Nk cell receptor]] | |||
[[Category: Receptor-ligand complex]] | |||