4k7q: Difference between revisions

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{{STRUCTURE_4k7q|  PDB=4k7q  |  SCENE=  }}
==Crystal Structure of AcrB Complexed with Linezolid at 3.5 Resolution==
===Crystal Structure of AcrB Complexed with Linezolid at 3.5 Resolution===
<StructureSection load='4k7q' size='340' side='right' caption='[[4k7q]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
{{ABSTRACT_PUBMED_23673416}}
== Structural highlights ==
<table><tr><td colspan='2'>[[4k7q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K7Q FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZLD:N-{[(5S)-3-(3-FLUORO-4-MORPHOLIN-4-YLPHENYL)-2-OXO-1,3-OXAZOLIDIN-5-YL]METHYL}ACETAMIDE'>ZLD</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">acrB, acrE, b0462, JW0451 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k7q RCSB], [http://www.ebi.ac.uk/pdbsum/4k7q PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
AcrB is an inner membrane resistance-nodulation-cell division efflux pump and is part of the AcrAB-TolC tripartite efflux system. We have determined the crystal structure of AcrB with bound Linezolid at a resolution of 3.5 A. The structure shows that Linezolid binds to the A385/F386 loops of the symmetric trimer of AcrB. A conformational change of a loop in the bottom of the periplasmic cleft is also observed.


==Function==
Crystal structure of AcrB complexed with linezolid at 3.5 A resolution.,Hung LW, Kim HB, Murakami S, Gupta G, Kim CY, Terwilliger TC J Struct Funct Genomics. 2013 Jun;14(2):71-5. doi: 10.1007/s10969-013-9154-x., Epub 2013 May 15. PMID:23673416<ref>PMID:23673416</ref>
[[http://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI]] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[4k7q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K7Q OCA].
</div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:023673416</ref><references group="xtra"/><references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli k-12]]
[[Category: Escherichia coli k-12]]
[[Category: Gupta, G.]]
[[Category: Gupta, G]]
[[Category: Hung, L W.]]
[[Category: Hung, L W]]
[[Category: Kim, C Y.]]
[[Category: Kim, C Y]]
[[Category: Kim, H B.]]
[[Category: Kim, H B]]
[[Category: Murakami, S.]]
[[Category: Murakami, S]]
[[Category: Terwilliger, T C.]]
[[Category: Terwilliger, T C]]
[[Category: Inner membrane resistance-nodulation-cell division efflux pump]]
[[Category: Inner membrane resistance-nodulation-cell division efflux pump]]
[[Category: Membrane protein-antibiotic complex]]
[[Category: Membrane protein-antibiotic complex]]
Retrieved from "https://proteopedia.org/4k7q"