3w9h: Difference between revisions
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{{STRUCTURE_3w9h| PDB=3w9h | SCENE= }} | {{STRUCTURE_3w9h| PDB=3w9h | SCENE= }} | ||
===Structural basis for the inhibition of bacterial multidrug exporters=== | ===Structural basis for the inhibition of bacterial multidrug exporters=== | ||
{{ABSTRACT_PUBMED_23812586}} | |||
==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
<references group="xtra"/><references/> | <ref group="xtra">PMID:023812586</ref><references group="xtra"/><references/> | ||
[[Category: Escherichia coli k-12]] | [[Category: Escherichia coli k-12]] | ||
[[Category: Nagata, C.]] | [[Category: Nagata, C.]] | ||
Revision as of 18:56, 7 August 2013
Structural basis for the inhibition of bacterial multidrug exporters
Template:ABSTRACT PUBMED 23812586
Function
[ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.[1] [2] [3]
About this Structure
3w9h is a 3 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.
Reference
- Nakashima R, Sakurai K, Yamasaki S, Hayashi K, Nagata C, Hoshino K, Onodera Y, Nishino K, Yamaguchi A. Structural basis for the inhibition of bacterial multidrug exporters. Nature. 2013 Aug 1;500(7460):102-6. doi: 10.1038/nature12300. Epub 2013 Jun 30. PMID:23812586 doi:10.1038/nature12300
- ↑ Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature. 2006 Sep 14;443(7108):173-9. Epub 2006 Aug 16. PMID:16915237 doi:10.1038/nature05076
- ↑ Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM. Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science. 2006 Sep 1;313(5791):1295-8. PMID:16946072 doi:313/5791/1295
- ↑ Sennhauser G, Amstutz P, Briand C, Storchenegger O, Grutter MG. Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol. 2007 Jan;5(1):e7. PMID:17194213 doi:10.1371/journal.pbio.0050007
