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{{STRUCTURE_4gcy| PDB=4gcy | SCENE= }}
==Structure of Mycobacterium tuberculosis dUTPase H21W mutant==
===Structure of Mycobacterium tuberculosis dUTPase H21W mutant===
<StructureSection load='4gcy' size='340' side='right' caption='[[4gcy]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4gcy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GCY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GCY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUP:2-DEOXYURIDINE+5-ALPHA,BETA-IMIDO-TRIPHOSPHATE'>DUP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2py4|2py4]], [[3hza|3hza]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dut, Rv2697c, MT2771, MTCY05A6.18c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gcy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gcy RCSB], [http://www.ebi.ac.uk/pdbsum/4gcy PDBsum]</span></td></tr>
</table>


==Function==
==See Also==
[[http://www.uniprot.org/uniprot/DUT_MYCTU DUT_MYCTU]] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116]  
*[[Deoxyuridine 5'-triphosphate nucleotidohydrolase|Deoxyuridine 5'-triphosphate nucleotidohydrolase]]
 
__TOC__
==About this Structure==
</StructureSection>
[[4gcy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GCY OCA].
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: DUTP diphosphatase]]
[[Category: DUTP diphosphatase]]
[[Category: Bendes, A.]]
[[Category: Bendes, A]]
[[Category: Leveles, I.]]
[[Category: Leveles, I]]
[[Category: Toth, J.]]
[[Category: Toth, J]]
[[Category: Vertessy, B G.]]
[[Category: Vertessy, B G]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Jelly-roll]]
[[Category: Jelly-roll]]

Revision as of 11:37, 21 December 2014

Structure of Mycobacterium tuberculosis dUTPase H21W mutant

4gcy, resolution 1.50Å

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