3wan: Difference between revisions
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{{STRUCTURE_3wan| PDB=3wan | SCENE= }} | |||
===Crystal structure of Atg13 LIR-fused human LC3A_2-121=== | |||
{{ABSTRACT_PUBMED_24290141}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ATG13_HUMAN ATG13_HUMAN]] Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.<ref>PMID:19287211</ref> <ref>PMID:19211835</ref> <ref>PMID:19225151</ref> <ref>PMID:21855797</ref> <ref>PMID:18936157</ref> <ref>PMID:21795849</ref> | |||
==About this Structure== | |||
[[3wan]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WAN OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024290141</ref><references group="xtra"/><references/> | |||
[[Category: Dobson, R C.J.]] | |||
[[Category: Kato, R.]] | |||
[[Category: Kawasaki, M.]] | |||
[[Category: Morita, E.]] | |||
[[Category: Suzuki, H.]] | |||
[[Category: Tabata, K.]] | |||
[[Category: Wakatsuki, S.]] | |||
[[Category: Yoshimori, T.]] | |||
[[Category: Autophagy]] | |||
[[Category: Protein binding]] | |||
[[Category: Ubiquitin-like fold]] | |||