4kxm: Difference between revisions
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{{STRUCTURE_4kxm| PDB=4kxm | SCENE= }} | |||
===Crystal structure of DNPH1 (RCL) WITH N6-ISOPENTENYL-AMP=== | |||
{{ABSTRACT_PUBMED_24260472}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DNPH1_RAT DNPH1_RAT]] Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.<ref>PMID:17234634</ref> | |||
==About this Structure== | |||
[[4kxm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KXM OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024260472</ref><references group="xtra"/><references/> | |||
[[Category: Kaminski, P A.]] | |||
[[Category: Labesse, G.]] | |||
[[Category: Padilla, A.]] | |||
[[Category: Deoxyribonucleoside 5'-monophosphate n-glycosidase]] | |||
[[Category: Hydrolase]] | |||
Revision as of 11:02, 5 February 2014
Crystal structure of DNPH1 (RCL) WITH N6-ISOPENTENYL-AMP
Template:ABSTRACT PUBMED 24260472
Function
[DNPH1_RAT] Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.[1]
About this Structure
4kxm is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- Amiable C, Pochet S, Padilla A, Labesse G, Kaminski PA. N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1. PLoS One. 2013 Nov 19;8(11):e80755. doi: 10.1371/journal.pone.0080755., eCollection 2013. PMID:24260472 doi:https://dx.doi.org/10.1371/journal.pone.0080755
- ↑ Ghiorghi YK, Zeller KI, Dang CV, Kaminski PA. The c-Myc target gene Rcl (C6orf108) encodes a novel enzyme, deoxynucleoside 5'-monophosphate N-glycosidase. J Biol Chem. 2007 Mar 16;282(11):8150-6. Epub 2007 Jan 18. PMID:17234634 doi:https://dx.doi.org/10.1074/jbc.M610648200
