4l9i: Difference between revisions
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{{STRUCTURE_4l9i| PDB=4l9i | SCENE= }} | |||
===Bovine G Protein Coupled Receptor Kinase 1 in Complex with Paroxetine=== | |||
{{ABSTRACT_PUBMED_24220010}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/RK_BOVIN RK_BOVIN]] Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). | |||
==About this Structure== | |||
[[4l9i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9I OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024220010</ref><references group="xtra"/><references/> | |||
[[Category: Rhodopsin kinase]] | |||
[[Category: Homan, K T.]] | |||
[[Category: Tesmer, J J.G.]] | |||
[[Category: Agc family kinase]] | |||
[[Category: G protein coupled receptor kinase]] | |||
[[Category: Gpcr]] | |||
[[Category: Grk]] | |||
[[Category: Grk1]] | |||
[[Category: Hydrolyase]] | |||
[[Category: Membrane protein-inhibitor complex]] | |||
[[Category: Phosphorylation]] | |||
[[Category: Rgs homology domain]] | |||
[[Category: Rhodopsin kinase]] | |||
[[Category: Ser/thr kinase]] | |||
[[Category: Ssri]] | |||
[[Category: Transferase]] | |||
Revision as of 06:54, 22 January 2014
Bovine G Protein Coupled Receptor Kinase 1 in Complex with Paroxetine
Template:ABSTRACT PUBMED 24220010
Function
[RK_BOVIN] Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity).
About this Structure
4l9i is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Homan KT, Wu E, Wilson MW, Singh P, Larsen SD, Tesmer JJ. Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog. Mol Pharmacol. 2014 Feb;85(2):237-48. doi: 10.1124/mol.113.089631. Epub 2013 Nov , 12. PMID:24220010 doi:https://dx.doi.org/10.1124/mol.113.089631
