4bqm: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of human liver-type glutaminase, catalytic domain== | |||
<StructureSection load='4bqm' size='340' side='right' caption='[[4bqm]], [[Resolution|resolution]] 2.18Å' scene=''> | |||
== Structural highlights == | |||
==Function== | <table><tr><td colspan='2'>[[4bqm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQM FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutaminase Glutaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.2 3.5.1.2] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bqm RCSB], [http://www.ebi.ac.uk/pdbsum/4bqm PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GLSL_HUMAN GLSL_HUMAN]] Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.<ref>PMID:20378837</ref> | [[http://www.uniprot.org/uniprot/GLSL_HUMAN GLSL_HUMAN]] Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.<ref>PMID:20378837</ref> | ||
== | ==See Also== | ||
[[ | *[[Glutaminase|Glutaminase]] | ||
== References == | |||
== | <references/> | ||
<references | __TOC__ | ||
</StructureSection> | |||
[[Category: Glutaminase]] | [[Category: Glutaminase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Ambrosio, A L.B | [[Category: Ambrosio, A L.B]] | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C | [[Category: Bountra, C]] | ||
[[Category: Burgess-Brown, N | [[Category: Burgess-Brown, N]] | ||
[[Category: Coutandin, D | [[Category: Coutandin, D]] | ||
[[Category: Delft, F von | [[Category: Delft, F von]] | ||
[[Category: Dias, S M.G | [[Category: Dias, S M.G]] | ||
[[Category: Edwards, A | [[Category: Edwards, A]] | ||
[[Category: Ferreira, I M | [[Category: Ferreira, I M]] | ||
[[Category: Froese, S | [[Category: Froese, S]] | ||
[[Category: Krojer, T | [[Category: Krojer, T]] | ||
[[Category: Strain-Damerell, C | [[Category: Strain-Damerell, C]] | ||
[[Category: Vollmar, M | [[Category: Vollmar, M]] | ||
[[Category: Williams, E | [[Category: Williams, E]] | ||
[[Category: Yue, W W | [[Category: Yue, W W]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
