4key: Difference between revisions
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{{STRUCTURE_4key| PDB=4key | SCENE= }} | {{STRUCTURE_4key| PDB=4key | SCENE= }} | ||
===Structure of P450 BM3 A82F F87V in complex with omeprazole=== | ===Structure of P450 BM3 A82F F87V in complex with omeprazole=== | ||
{{ABSTRACT_PUBMED_23828198}} | |||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4key]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KEY OCA]. | [[4key]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KEY OCA]. | ||
==See Also== | |||
*[[Cytochrome P450|Cytochrome P450]] | |||
==Reference== | |||
<ref group="xtra">PMID:023828198</ref><references group="xtra"/><references/> | |||
[[Category: Bacillus megaterium]] | [[Category: Bacillus megaterium]] | ||
[[Category: Leys, D.]] | [[Category: Leys, D.]] | ||
Revision as of 06:11, 2 October 2013
Structure of P450 BM3 A82F F87V in complex with omeprazole
Template:ABSTRACT PUBMED 23828198
Function
[CPXB_BACME] Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of medium and long-chain fatty acids at omega-1, omega-2 and omega-3 positions, with optimum chain lengths of 12-16 carbons (lauric, myristic, and palmitic acids). The reductase domain is required for electron transfer from NADP to cytochrome P450.
About this Structure
4key is a 2 chain structure with sequence from Bacillus megaterium. Full crystallographic information is available from OCA.
See Also
Reference
- Butler CF, Peet C, Mason AE, Voice MW, Leys D, Munro AW. Key Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate Bias. J Biol Chem. 2013 Aug 30;288(35):25387-99. doi: 10.1074/jbc.M113.479717. Epub, 2013 Jul 3. PMID:23828198 doi:10.1074/jbc.M113.479717
