2iko: Difference between revisions

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[[Image:2iko.gif|left|200px]]<br /><applet load="2iko" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2iko.gif|left|200px]]
caption="2iko, resolution 1.900&Aring;" />
 
'''Crystal Structure of Human Renin Complexed with Inhibitor'''<br />
{{Structure
|PDB= 2iko |SIZE=350|CAPTION= <scene name='initialview01'>2iko</scene>, resolution 1.900&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=7IG:5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE'>7IG</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15]
|GENE= REN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal Structure of Human Renin Complexed with Inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2IKO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=7IG:'>7IG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IKO OCA].  
2IKO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IKO OCA].  


==Reference==
==Reference==
Binding thermodynamics of substituted diaminopyrimidine renin inhibitors., Sarver RW, Peevers J, Cody WL, Ciske FL, Dyer J, Emerson SD, Hagadorn JC, Holsworth DD, Jalaie M, Kaufman M, Mastronardi M, McConnell P, Powell NA, Quin J 3rd, Van Huis CA, Zhang E, Mochalkin I, Anal Biochem. 2007 Jan 1;360(1):30-40. Epub 2006 Oct 30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17113558 17113558]
Binding thermodynamics of substituted diaminopyrimidine renin inhibitors., Sarver RW, Peevers J, Cody WL, Ciske FL, Dyer J, Emerson SD, Hagadorn JC, Holsworth DD, Jalaie M, Kaufman M, Mastronardi M, McConnell P, Powell NA, Quin J 3rd, Van Huis CA, Zhang E, Mochalkin I, Anal Biochem. 2007 Jan 1;360(1):30-40. Epub 2006 Oct 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17113558 17113558]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Renin]]
[[Category: Renin]]
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[[Category: 7IG]]
[[Category: 7IG]]
[[Category: drug design]]
[[Category: drug design]]
[[Category: inhibitors]]
[[Category: inhibitor]]
[[Category: renin]]
[[Category: renin]]


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