2il2: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:2il2.gif|left|200px]]<br /><applet load="2il2" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2il2.gif|left|200px]]
caption="2il2, resolution 2.240&Aring;" />
 
'''Crystal Structure of Human Renin Complexed with Inhibitor'''<br />
{{Structure
|PDB= 2il2 |SIZE=350|CAPTION= <scene name='initialview01'>2il2</scene>, resolution 2.240&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=LIX:N-[2-({2-AMINO-6-ETHYL-5-[4-(3-METHOXYPROPYL)-2,2-DIMETHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-YL]PYRIMIDIN-4-YL}AMINO)ETHYL]NAPHTHALENE-2-SULFONAMIDE'>LIX</scene> and <scene name='pdbligand=CIT:CITRIC ACID'>CIT</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15]
|GENE=
}}
 
'''Crystal Structure of Human Renin Complexed with Inhibitor'''
 


==Overview==
==Overview==
Line 10: Line 19:


==About this Structure==
==About this Structure==
2IL2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=LIX:'>LIX</scene> and <scene name='pdbligand=CIT:'>CIT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL2 OCA].  
2IL2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL2 OCA].  


==Reference==
==Reference==
Binding thermodynamics of substituted diaminopyrimidine renin inhibitors., Sarver RW, Peevers J, Cody WL, Ciske FL, Dyer J, Emerson SD, Hagadorn JC, Holsworth DD, Jalaie M, Kaufman M, Mastronardi M, McConnell P, Powell NA, Quin J 3rd, Van Huis CA, Zhang E, Mochalkin I, Anal Biochem. 2007 Jan 1;360(1):30-40. Epub 2006 Oct 30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17113558 17113558]
Binding thermodynamics of substituted diaminopyrimidine renin inhibitors., Sarver RW, Peevers J, Cody WL, Ciske FL, Dyer J, Emerson SD, Hagadorn JC, Holsworth DD, Jalaie M, Kaufman M, Mastronardi M, McConnell P, Powell NA, Quin J 3rd, Van Huis CA, Zhang E, Mochalkin I, Anal Biochem. 2007 Jan 1;360(1):30-40. Epub 2006 Oct 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17113558 17113558]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Renin]]
[[Category: Renin]]
Line 21: Line 30:
[[Category: LIX]]
[[Category: LIX]]
[[Category: drug design]]
[[Category: drug design]]
[[Category: inhibitors]]
[[Category: inhibitor]]
[[Category: renin]]
[[Category: renin]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:53:39 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:30:41 2008''
Retrieved from "https://proteopedia.org/2il2"