2imb: Difference between revisions

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[[Image:2imb.jpg|left|200px]]<br /><applet load="2imb" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2imb.jpg|left|200px]]
caption="2imb, resolution 2.41&Aring;" />
 
'''Clostridium botulinum Neurotoxin Serotype A Light Chain Inhibited by L-arginine hydroxamate'''<br />
{{Structure
|PDB= 2imb |SIZE=350|CAPTION= <scene name='initialview01'>2imb</scene>, resolution 2.41&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=AHL:N-HYDROXY-L-ARGININAMIDE'>AHL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69]
|GENE= botA, atx, bna ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 Clostridium botulinum])
}}
 
'''Clostridium botulinum Neurotoxin Serotype A Light Chain Inhibited by L-arginine hydroxamate'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2IMB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=AHL:'>AHL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IMB OCA].  
2IMB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IMB OCA].  


==Reference==
==Reference==
Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility., Silvaggi NR, Boldt GE, Hixon MS, Kennedy JP, Tzipori S, Janda KD, Allen KN, Chem Biol. 2007 May;14(5):533-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17524984 17524984]
Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility., Silvaggi NR, Boldt GE, Hixon MS, Kennedy JP, Tzipori S, Janda KD, Allen KN, Chem Biol. 2007 May;14(5):533-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17524984 17524984]
[[Category: Bontoxilysin]]
[[Category: Bontoxilysin]]
[[Category: Clostridium botulinum]]
[[Category: Clostridium botulinum]]
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[[Category: AHL]]
[[Category: AHL]]
[[Category: ZN]]
[[Category: ZN]]
[[Category: clostridium botulinum neurotoxin serotype a]]
[[Category: clostridium botulinum neurotoxin serotype some]]
[[Category: protease inhibitors]]
[[Category: protease inhibitor]]
[[Category: substrate specificity]]
[[Category: substrate specificity]]
[[Category: substrate switching]]
[[Category: substrate switching]]


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