4lii: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of an apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1) from Homo sapiens at 1.88 A resolution===

~~The~~ entry ~~4lii~~ is ~~ON HOLD~~

==Disease==

[[http://www.uniprot.org/uniprot/AIFM1_HUMAN AIFM1_HUMAN]] Defects in AIFM1 are the cause of combined oxidative phosphorylation deficiency type 6 (COXPD6) [MIM:[http://omim.org/entry/300816 300816]]. It is a mitochondrial disease resulting in a neurodegenerative disorder characterized by psychomotor delay, hypotonia, areflexia, muscle weakness and wasting.<ref>PMID:20362274</ref> <ref>PMID:22019070</ref>

~~Authors~~: ~~Joint Center for Structural Genomics~~ (~~JCSG~~), ~~Partnership for T~~-~~Cell Biology (TCELL)~~

==Function==

[[http://www.uniprot.org/uniprot/AIFM1_HUMAN AIFM1_HUMAN]] Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.<ref>PMID:17094969</ref> <ref>PMID:19418225</ref> <ref>PMID:20362274</ref>

~~Description~~: ~~Crystal structure of an apoptosis~~-~~inducing factor~~, ~~mitochondrion~~-~~associated, 1 (AIFM1) from Homo sapiens at 1~~.~~88 A resolution~~

==About this Structure==

[[4lii]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LII OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: JCSG, Joint Center for Structural Genomics.]]

[[Category: TCELL, Partnership for T-Cell Biology.]]

[[Category: Apoptosis]]

[[Category: Fad/nad-linked reductase]]

[[Category: Flavoprotein]]

[[Category: Jcsg]]

[[Category: Joint center for structural genomic]]

[[Category: Oxidoreductase]]

[[Category: Protein structure initiative]]

[[Category: Psi-biology]]

[[Category: Structural genomic]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4lii|  PDB=4lii  |  SCENE=  }}
+===Crystal structure of an apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1) from Homo sapiens at 1.88 A resolution===
-The entry 4lii is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/AIFM1_HUMAN AIFM1_HUMAN]] Defects in AIFM1 are the cause of combined oxidative phosphorylation deficiency type 6 (COXPD6) [MIM:[http://omim.org/entry/300816 300816]]. It is a mitochondrial disease resulting in a neurodegenerative disorder characterized by psychomotor delay, hypotonia, areflexia, muscle weakness and wasting.<ref>PMID:20362274</ref> <ref>PMID:22019070</ref>
-Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL)
+==Function==
+[[http://www.uniprot.org/uniprot/AIFM1_HUMAN AIFM1_HUMAN]] Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.<ref>PMID:17094969</ref> <ref>PMID:19418225</ref> <ref>PMID:20362274</ref>
-Description: Crystal structure of an apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1) from Homo sapiens at 1.88 A resolution
+==About this Structure==
+[[4lii]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LII OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: JCSG, Joint Center for Structural Genomics.]]
+[[Category: TCELL, Partnership for T-Cell Biology.]]
+[[Category: Apoptosis]]
+[[Category: Fad/nad-linked reductase]]
+[[Category: Flavoprotein]]
+[[Category: Jcsg]]
+[[Category: Joint center for structural genomic]]
+[[Category: Oxidoreductase]]
+[[Category: Protein structure initiative]]
+[[Category: Psi-biology]]
+[[Category: Structural genomic]]