2inq: Difference between revisions

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[[Image:2inq.gif|left|200px]]<br /><applet load="2inq" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2inq.gif|left|200px]]
caption="2inq, resolution 2.20&Aring;" />
 
'''Neutron Crystal Structure of Escherichia coli Dihydrofolate Reductase Bound to the Anti-cancer drug, Methotrexate'''<br />
{{Structure
|PDB= 2inq |SIZE=350|CAPTION= <scene name='initialview01'>2inq</scene>, resolution 2.20&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MT1:N-(4-{[(2,4-DIAMINOPTERIDIN-1-IUM-6-YL)METHYL](METHYL)AMINO}BENZOYL)-L-GLUTAMIC ACID'>MT1</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]
|GENE= folA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
}}
 
'''Neutron Crystal Structure of Escherichia coli Dihydrofolate Reductase Bound to the Anti-cancer drug, Methotrexate'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2INQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=MT1:'>MT1</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2INQ OCA].  
2INQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2INQ OCA].  


==Reference==
==Reference==
Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate., Bennett B, Langan P, Coates L, Mustyakimov M, Schoenborn B, Howell EE, Dealwis C, Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18493-8. Epub 2006 Nov 27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17130456 17130456]
Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate., Bennett B, Langan P, Coates L, Mustyakimov M, Schoenborn B, Howell EE, Dealwis C, Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18493-8. Epub 2006 Nov 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17130456 17130456]
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: neutron structure; deuterium exchange; pseudo-rossman fold; nucleotide binding domain; chemotherapy]]
[[Category: neutron structure; deuterium exchange; pseudo-rossman fold; nucleotide binding domain; chemotherapy]]


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