4lk6: Difference between revisions
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{{STRUCTURE_4lk6| PDB=4lk6 | SCENE= }} | |||
===Crystal Structure of Pseudomonas aeruginosa Lectin LecA Complexed with Chlorophenol Red-b-D-galactopyranoside at 2.86 A Resolution=== | |||
{{ABSTRACT_PUBMED_23869965}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PA1L_PSEAE PA1L_PSEAE]] D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity. | |||
==About this Structure== | |||
[[4lk6]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LK6 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023869965</ref><references group="xtra"/><references/> | |||
[[Category: Pseudomonas aeruginosa pao1]] | |||
[[Category: Kadam, R U.]] | |||
[[Category: Reymond, J L.]] | |||
[[Category: Stocker, A.]] | |||
[[Category: Galactose]] | |||
[[Category: Lectin fold]] | |||
[[Category: Sugar binding protein]] | |||
Revision as of 09:32, 30 October 2013
Crystal Structure of Pseudomonas aeruginosa Lectin LecA Complexed with Chlorophenol Red-b-D-galactopyranoside at 2.86 A Resolution
Template:ABSTRACT PUBMED 23869965
Function
[PA1L_PSEAE] D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity.
About this Structure
4lk6 is a 12 chain structure with sequence from Pseudomonas aeruginosa pao1. Full crystallographic information is available from OCA.
Reference
- Kadam RU, Garg D, Schwartz J, Visini R, Sattler M, Stocker A, Darbre T, Reymond JL. CH-pi "T-Shape" Interaction with Histidine Explains Binding of Aromatic Galactosides to Pseudomonas aeruginosa Lectin LecA. ACS Chem Biol. 2013 Sep 20;8(9):1925-30. doi: 10.1021/cb400303w. Epub 2013 Jul, 31. PMID:23869965 doi:https://dx.doi.org/10.1021/cb400303w
