2ipf: Difference between revisions

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[[Image:2ipf.gif|left|200px]]<br /><applet load="2ipf" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2ipf.gif|left|200px]]
caption="2ipf, resolution 1.850&Aring;" />
 
'''Crystal structure of 17alpha-hydroxysteroid dehydrogenase in complex with NADP+ and epi-testosterone'''<br />
{{Structure
|PDB= 2ipf |SIZE=350|CAPTION= <scene name='initialview01'>2ipf</scene>, resolution 1.850&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=FFA:(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE'>FFA</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene> and <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>
|ACTIVITY=
|GENE= Akr1c21 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
}}
 
'''Crystal structure of 17alpha-hydroxysteroid dehydrogenase in complex with NADP+ and epi-testosterone'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2IPF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NAP:'>NAP</scene>, <scene name='pdbligand=FFA:'>FFA</scene>, <scene name='pdbligand=BME:'>BME</scene>, <scene name='pdbligand=EDO:'>EDO</scene> and <scene name='pdbligand=TRS:'>TRS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPF OCA].  
2IPF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPF OCA].  


==Reference==
==Reference==
Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding., Faucher F, Cantin L, Pereira de Jesus-Tran K, Lemieux M, Luu-The V, Labrie F, Breton R, J Mol Biol. 2007 Jun 1;369(2):525-40. Epub 2007 Mar 27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17442338 17442338]
Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding., Faucher F, Cantin L, Pereira de Jesus-Tran K, Lemieux M, Luu-The V, Labrie F, Breton R, J Mol Biol. 2007 Jun 1;369(2):525-40. Epub 2007 Mar 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17442338 17442338]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: open conformation]]
[[Category: open conformation]]


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