4k5y: Difference between revisions
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{{STRUCTURE_4k5y| PDB=4k5y | SCENE= }} | {{STRUCTURE_4k5y| PDB=4k5y | SCENE= }} | ||
===Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395=== | ===Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395=== | ||
{{ABSTRACT_PUBMED_23863939}} | |||
==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
<references group="xtra"/><references/> | <ref group="xtra">PMID:023863939</ref><references group="xtra"/><references/> | ||
[[Category: Bortolato, A.]] | [[Category: Bortolato, A.]] | ||
[[Category: Cheng, R K.Y.]] | [[Category: Cheng, R K.Y.]] | ||
Revision as of 05:14, 23 October 2013
Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395
Template:ABSTRACT PUBMED 23863939
Function
[CRFR1_HUMAN] Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.[1]
About this Structure
4k5y is a 3 chain structure. Full crystallographic information is available from OCA.
Reference
- Hollenstein K, Kean J, Bortolato A, Cheng RK, Dore AS, Jazayeri A, Cooke RM, Weir M, Marshall FH. Structure of class B GPCR corticotropin-releasing factor receptor 1. Nature. 2013 Jul 25;499(7459):438-43. doi: 10.1038/nature12357. Epub 2013 Jul 17. PMID:23863939 doi:https://dx.doi.org/10.1038/nature12357
- ↑ Pioszak AA, Parker NR, Suino-Powell K, Xu HE. Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1. J Biol Chem. 2008 Nov 21;283(47):32900-12. Epub 2008 Sep 17. PMID:18801728 doi:10.1074/jbc.M805749200
