2iut: Difference between revisions
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[[Image:2iut.gif|left|200px]] | [[Image:2iut.gif|left|200px]] | ||
'''P. AERUGINOSA FTSK MOTOR DOMAIN, DIMERIC''' | {{Structure | ||
|PDB= 2iut |SIZE=350|CAPTION= <scene name='initialview01'>2iut</scene>, resolution 2.25Å | |||
|SITE= <scene name='pdbsite=AC1:Atg+Binding+Site+For+Chain+B'>AC1</scene> | |||
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=ATG:PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER'>ATG</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''P. AERUGINOSA FTSK MOTOR DOMAIN, DIMERIC''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2IUT is a [ | 2IUT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUT OCA]. | ||
==Reference== | ==Reference== | ||
Double-stranded DNA translocation: structure and mechanism of hexameric FtsK., Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J, Mol Cell. 2006 Aug;23(4):457-69. PMID:[http:// | Double-stranded DNA translocation: structure and mechanism of hexameric FtsK., Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J, Mol Cell. 2006 Aug;23(4):457-69. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16916635 16916635] | ||
[[Category: Pseudomonas aeruginosa]] | [[Category: Pseudomonas aeruginosa]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: hexameric ring]] | [[Category: hexameric ring]] | ||
[[Category: inner membrane]] | [[Category: inner membrane]] | ||
[[Category: | [[Category: kop]] | ||
[[Category: membrane]] | [[Category: membrane]] | ||
[[Category: membrane protein]] | [[Category: membrane protein]] | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:33:41 2008'' | ||
Revision as of 15:33, 20 March 2008
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| 2iut, resolution 2.25Å | |||||||||||||
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| Sites: | AC1 | ||||||||||||
| Ligands: | MG and ATG | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
P. AERUGINOSA FTSK MOTOR DOMAIN, DIMERIC
Overview
FtsK is a DNA translocase that coordinates chromosome segregation and cell division in bacteria. In addition to its role as activator of XerCD site-specific recombination, FtsK can translocate double-stranded DNA (dsDNA) rapidly and directionally and reverse direction. We present crystal structures of the FtsK motor domain monomer, showing that it has a RecA-like core, the FtsK hexamer, and also showing that it is a ring with a large central annulus and a dodecamer consisting of two hexamers, head to head. Electron microscopy (EM) demonstrates the DNA-dependent existence of hexamers in solution and shows that duplex DNA passes through the middle of each ring. Comparison of FtsK monomer structures from two different crystal forms highlights a conformational change that we propose is the structural basis for a rotary inchworm mechanism of DNA translocation.
About this Structure
2IUT is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.
Reference
Double-stranded DNA translocation: structure and mechanism of hexameric FtsK., Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J, Mol Cell. 2006 Aug;23(4):457-69. PMID:16916635
Page seeded by OCA on Thu Mar 20 17:33:41 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Pseudomonas aeruginosa
- Single protein
- Lowe, J.
- Massey, T H.
- Mercogliano, C P.
- Sherratt, D J.
- Yates, J.
- ATG
- MG
- Aaa atpase
- Atp-binding
- Cell cycle
- Cell division
- Chromosome partition
- Divisome
- Dna translocation
- Dna-binding
- Hexameric ring
- Inner membrane
- Kop
- Membrane
- Membrane protein
- Nucleotide-binding
- Transmembrane
