3wdz: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Crystal Structure of Keap1 in Complex with phosphorylated p62===

~~The entry 3wdz is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE]] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref> [[http://www.uniprot.org/uniprot/SQSTM_MOUSE SQSTM_MOUSE]] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.<ref>PMID:14960283</ref> <ref>PMID:18382763</ref>

~~Authors~~: ~~Fukutomi, T~~.~~, Takagi, K~~.~~, Mizushima, T~~.~~, Tanaka, K~~.~~, Komatsu, M~~.~~, Yamamoto, M~~.

==About this Structure==

[[3wdz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WDZ OCA].

~~Description~~: ~~Crystal Structure of Keap1 in Complex with phosphorylated p62~~

==Reference==

[[Category: Mus musculus]]

[[Category: Fukutomi, T.]]

[[Category: Komatsu, M.]]

[[Category: Mizushima, T.]]

[[Category: Takagi, K.]]

[[Category: Tanaka, K.]]

[[Category: Yamamoto, M.]]

[[Category: Kelch repeat]]

[[Category: Nucleus]]

[[Category: P62]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_3wdz|  PDB=3wdz  |  SCENE=  }}
+===Crystal Structure of Keap1 in Complex with phosphorylated p62===
-The entry 3wdz is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE]] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref>  [[http://www.uniprot.org/uniprot/SQSTM_MOUSE SQSTM_MOUSE]] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.<ref>PMID:14960283</ref> <ref>PMID:18382763</ref>
-Authors: Fukutomi, T., Takagi, K., Mizushima, T., Tanaka, K., Komatsu, M., Yamamoto, M.
+==About this Structure==
+[[3wdz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WDZ OCA].
-Description: Crystal Structure of Keap1 in Complex with phosphorylated p62
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Mus musculus]]
+[[Category: Fukutomi, T.]]
+[[Category: Komatsu, M.]]
+[[Category: Mizushima, T.]]
+[[Category: Takagi, K.]]
+[[Category: Tanaka, K.]]
+[[Category: Yamamoto, M.]]
+[[Category: Kelch repeat]]
+[[Category: Nucleus]]
+[[Category: P62]]
+[[Category: Transcription]]