4bxs: Difference between revisions
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{{STRUCTURE_4bxs| PDB=4bxs | SCENE= }} | |||
===Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis=== | |||
{{ABSTRACT_PUBMED_23869089}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FA5V_PSETE FA5V_PSETE]] Snake prothrombin activator that attacks the hemostatic system of prey. This non-catalytic subunit is functionally similar to blood coagulation factor V. It serves as a critical cofactor for the prothrombinase activity of the catalytic subunit, which is similar to the blood coagulation factor X.<ref>PMID:12362232</ref> | |||
==About this Structure== | |||
[[4bxs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudonaja_textilis Pseudonaja textilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BXS OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023869089</ref><references group="xtra"/><references/> | |||
[[Category: Pseudonaja textilis]] | |||
[[Category: Adams, T E.]] | |||
[[Category: Camire, R M.]] | |||
[[Category: Huntington, J A.]] | |||
[[Category: Johnson, D J.D.]] | |||
[[Category: Krishnaswamy, S.]] | |||
[[Category: Lechtenberg, B C.]] | |||
[[Category: Murray-Rust, T A.]] | |||
[[Category: Blood clotting]] | |||
[[Category: Blood coagulation]] | |||
[[Category: Hydrolase]] | |||
[[Category: Prothrombinase]] | |||
Revision as of 05:14, 1 August 2013
Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis
Template:ABSTRACT PUBMED 23869089
Function
[FA5V_PSETE] Snake prothrombin activator that attacks the hemostatic system of prey. This non-catalytic subunit is functionally similar to blood coagulation factor V. It serves as a critical cofactor for the prothrombinase activity of the catalytic subunit, which is similar to the blood coagulation factor X.[1]
About this Structure
4bxs is a 2 chain structure with sequence from Pseudonaja textilis. Full crystallographic information is available from OCA.
Reference
- Lechtenberg BC, Murray-Rust TA, Johnson DJ, Adams TE, Krishnaswamy S, Camire RM, Huntington JA. Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis. Blood. 2013 Jul 18. PMID:23869089 doi:10.1182/blood-2013-06-511733
- ↑ Rao VS, Kini RM. Pseutarin C, a prothrombin activator from Pseudonaja textilis venom: its structural and functional similarity to mammalian coagulation factor Xa-Va complex. Thromb Haemost. 2002 Oct;88(4):611-9. PMID:12362232 doi:10.1267/th02100611
