4kty: Difference between revisions
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{{STRUCTURE_4kty| PDB=4kty | SCENE= }} | |||
===Fibrin-stabilizing factor with a bound ligand=== | |||
{{ABSTRACT_PUBMED_24115223}} | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/F13A_HUMAN F13A_HUMAN]] Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD) [MIM:[http://omim.org/entry/613225 613225]]. FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.<ref>PMID:1353995</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/F13A_HUMAN F13A_HUMAN]] Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. | |||
==About this Structure== | |||
[[4kty]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KTY OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024115223</ref><references group="xtra"/><references/> | |||
[[Category: Protein-glutamine gamma-glutamyltransferase]] | |||
[[Category: Heine, A.]] | |||
[[Category: Klebe, G.]] | |||
[[Category: Stieler, M.]] | |||
[[Category: Acyltransferase]] | |||
[[Category: Calcium ion]] | |||
[[Category: Coagulation]] | |||
[[Category: Ligand]] | |||
[[Category: Transferase]] | |||
[[Category: Transferase-transferase inhibitor complex]] | |||
[[Category: Transglutaminase]] | |||
Revision as of 07:17, 4 December 2013
Fibrin-stabilizing factor with a bound ligand
Template:ABSTRACT PUBMED 24115223
Disease
[F13A_HUMAN] Defects in F13A1 are the cause of factor XIII subunit A deficiency (FA13AD) [MIM:613225]. FA13AD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.[1]
Function
[F13A_HUMAN] Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
About this Structure
4kty is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- Stieler M, Weber J, Hils M, Kolb P, Heine A, Buchold C, Pasternack R, Klebe G. Structure of Active Coagulation Factor XIII Triggered by Calcium Binding: Basis for the Design of Next-Generation Anticoagulants. Angew Chem Int Ed Engl. 2013 Sep 20. doi: 10.1002/anie.201305133. PMID:24115223 doi:https://dx.doi.org/10.1002/anie.201305133
