4li0: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of GDP-bound Rab8:GRAB===

~~The entry 4li0 is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/RAB8A_HUMAN RAB8A_HUMAN]] May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization.<ref>PMID:20890297</ref> <ref>PMID:21282656</ref> [[http://www.uniprot.org/uniprot/R3GEF_HUMAN R3GEF_HUMAN]] Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B.

~~Authors~~: ~~Guo, Z~~.~~, Hou, X~~.M.~~, Goody, R~~.S.~~, Itzen, A~~.

==About this Structure==

[[4li0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LI0 OCA].

~~Description~~: ~~Crystal structure of GDP-bound Rab8~~:~~GRAB~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Goody, R S.]]

[[Category: Guo, Z.]]

[[Category: Hou, X M.]]

[[Category: Itzen, A.]]

[[Category: Guanine nucleotide exchange factor]]

[[Category: Protein transport]]

[[Category: Small gtpase]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4li0|  PDB=4li0  |  SCENE=  }}
+===Crystal structure of GDP-bound Rab8:GRAB===
+{{ABSTRACT_PUBMED_24072714}}
-The entry 4li0 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/RAB8A_HUMAN RAB8A_HUMAN]] May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization.<ref>PMID:20890297</ref> <ref>PMID:21282656</ref>  [[http://www.uniprot.org/uniprot/R3GEF_HUMAN R3GEF_HUMAN]] Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B.
-Authors: Guo, Z., Hou, X.M., Goody, R.S., Itzen, A.
+==About this Structure==
+[[4li0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LI0 OCA].
-Description: Crystal structure of GDP-bound Rab8:GRAB
+==Reference==
+<ref group="xtra">PMID:024072714</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Goody, R S.]]
+[[Category: Guo, Z.]]
+[[Category: Hou, X M.]]
+[[Category: Itzen, A.]]
+[[Category: Guanine nucleotide exchange factor]]
+[[Category: Protein transport]]
+[[Category: Small gtpase]]