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{{STRUCTURE_4ieg|  PDB=4ieg  |  SCENE=  }}
==Structure and interactions of the RNA-dependent RNA polymerase from bacteriophage phi12 (P1 crystal form)==
===Structure and interactions of the RNA-dependent RNA polymerase from bacteriophage phi12 (P1 crystal form)===
<StructureSection load='4ieg' size='340' side='right' caption='[[4ieg]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
{{ABSTRACT_PUBMED_23568335}}
== Structural highlights ==
<table><tr><td colspan='2'>[[4ieg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_phage_phi12 Pseudomonas phage phi12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IEG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IEG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gzk|4gzk]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">P2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=161736 Pseudomonas phage phi12])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ieg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ieg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ieg RCSB], [http://www.ebi.ac.uk/pdbsum/4ieg PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We have determined the structure of P2, the self-priming RdRp from cystovirus varphi12 in two crystal forms (A, B) at resolutions of 1.7 A and 2.1 A. Form A contains Mg(2+) bound at a site that deviates from the canonical noncatalytic position seen in form B. These structures provide insight into the temperature sensitivity of a ts-mutant. However, the tunnel through which template ssRNA accesses the active site is partially occluded by a flexible loop; this feature, along with suboptimal positioning of other structural elements that prevent the formation of a stable initiation complex, indicate an inactive conformation in crystallo. Proteins 2013; 81:1479-1484. (c) 2013 Wiley Periodicals, Inc.


==About this Structure==
Structure of the RNA-directed RNA Polymerase from the cystovirus varphi12.,Ren Z, C Franklin M, Ghose R Proteins. 2013 Aug;81(8):1479-84. doi: 10.1002/prot.24297. Epub 2013 Jun 1. PMID:23568335<ref>PMID:23568335</ref>
[[4ieg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_phage_phi12 Pseudomonas phage phi12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IEG OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<ref group="xtra">PMID:023568335</ref><references group="xtra"/><references/>
</div>
 
==See Also==
*[[RNA polymerase|RNA polymerase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Pseudomonas phage phi12]]
[[Category: Pseudomonas phage phi12]]
[[Category: Franklin, M C.]]
[[Category: Franklin, M C]]
[[Category: Ghose, R.]]
[[Category: Ghose, R]]
[[Category: Ren, Z.]]
[[Category: Ren, Z]]
[[Category: Rna-directed rna polymerase]]
[[Category: Rna-directed rna polymerase]]
[[Category: Transferase]]
[[Category: Transferase]]
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