4i2e: Difference between revisions
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{{STRUCTURE_4i2e| PDB=4i2e | SCENE= }} | {{STRUCTURE_4i2e| PDB=4i2e | SCENE= }} | ||
===Ternary complex of mouse TdT with ssDNA and AMPcPP=== | ===Ternary complex of mouse TdT with ssDNA and AMPcPP=== | ||
{{ABSTRACT_PUBMED_23856622}} | |||
==Function== | ==Function== | ||
| Line 7: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
[[4i2e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I2E OCA]. | [[4i2e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I2E OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023856622</ref><references group="xtra"/><references/> | |||
[[Category: DNA nucleotidylexotransferase]] | [[Category: DNA nucleotidylexotransferase]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
Revision as of 03:25, 1 August 2013
Ternary complex of mouse TdT with ssDNA and AMPcPP
Template:ABSTRACT PUBMED 23856622
Function
[TDT_MOUSE] Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
About this Structure
4i2e is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Gouge J, Rosario S, Romain F, Beguin P, Delarue M. Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism. J Mol Biol. 2013 Jul 13. pii: S0022-2836(13)00441-5. doi:, 10.1016/j.jmb.2013.07.009. PMID:23856622 doi:10.1016/j.jmb.2013.07.009
