4lg9: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4lg9|  PDB=4lg9  |  SCENE=  }}
===Crystal structure of TBL1XR1 WD40 repeats===


The entry 4lg9 is ON HOLD
==Function==
[[http://www.uniprot.org/uniprot/TBL1R_HUMAN TBL1R_HUMAN]] F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.<ref>PMID:14980219</ref> 


Authors: Xu, C., Tempel, W., He, H., Wu, X., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
==About this Structure==
[[4lg9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG9 OCA].  


Description: Crystal structure of TBL1XR1 WD40 repeats
==Reference==
<references group="xtra"/><references/>
[[Category: Arrowsmith, C H.]]
[[Category: Bountra, C.]]
[[Category: Edwards, A M.]]
[[Category: He, H.]]
[[Category: Min, J.]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Tempel, W.]]
[[Category: Wu, X.]]
[[Category: Xu, C.]]
[[Category: Sgc]]
[[Category: Structural genomics consortium]]
[[Category: Unknown function]]
[[Category: Wd40 repeat]]

Revision as of 10:02, 16 April 2014

Template:STRUCTURE 4lg9

Crystal structure of TBL1XR1 WD40 repeats

Function

[TBL1R_HUMAN] F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.[1]

About this Structure

4lg9 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell. 2004 Feb 20;116(4):511-26. PMID:14980219

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